Stem Cell Therapy for Ovarian Failure

Stem Cell Therapy for Ovarian Failure

"Best medical decision I ever made! The stem cell procedure is quick, easy and has no recovery down time! Great alternative to surgery if that is an option."

By R3 Stem Cell Pakistan

The ovaries are responsible for two reproductive functions. Along with the production of egg cells (ova), the ovaries are also a part of the endocrine system. This means that ovaries also control the production of reproductive hormones like progesterone and estrogen.

The ovaries directly respond to the hormones released from the hypothalamus and pituitary glands to maintain a proper menstrual cycle. However, an irregular or nonexistent menstrual period before the age of 40, indicates inadequate ovarian function. This condition is known as ovarian failure or ovarian insufficiency. In many cases, ovarian insufficiency leads to premature cessation of menstruation and infertility. The disorder can progressively get worse if left untreated. This article explores how stem cell therapy for ovarian failure can help in treating the disorder.

Table of Contents

Types of Ovarian Failure

There are two main types of ovarian dysfunction. 

- Primary Ovarian Failure:

Also known as premature ovarian failure, the disorder occurs when the ovaries themselves stop functioning. The symptoms of this type of ovarian insufficiency are similar to those of menopause. Ovaries stop ovulating and produce reproductive hormones regularly. 

Around 90% of primary ovarian failure patients face infertility, hormonal imbalance, and obesity. Issues like autoimmune conditions, genetic impairments, eating disorders, ovarian infections, and hormonal disparity can cause primary ovarian insufficiency.

- Secondary Ovarian Failure:

This type of ovarian failure occurs when a lack of signal coordination occurs between the brain and the ovaries. The main issue lies with the hypothalamus or pituitary gland. Eating disorders, excessive physical activity, drug abuse, and certain prescribed medications can lead to secondary ovarian failure.

Ovarian insufficiency is chiefly challenging due to the lack of available treatments. Accessible options like estrogen therapy or calcium supplements can only delay the condition from progressing into osteoporosis or heart disease. However, physicians claim recent developments in regenerative medicine can potentially aid patients with ovarian dysfunctions.

Treating Ovarian Failure with Stem Cell Therapy

Cellular therapy or regenerative medicine focuses on the body’s natural regenerative abilities. Our bodies consist of master cells known as stem cells. These cells have natural anti-inflammatory and immunomodulatory properties that can treat a wide range of diseases. Firstly, when these cells are administered to the premature ovarian failure patient they replicate and grow in number. This self-renewing ability allows them to travel to multiple sites of damage at the same. In patients with ovarian failure, these cells target both the ovaries and hormonal glands in the brain. 

Secondly, these cells differentiate into lineage-specific cells. This enables them to regenerate the damaged organs. In patients with ovarian insufficiency, stem cells exhibit the potential of forming new blood vessels and ovarian follicles. Lastly, upon entering a micro-environment these cells adapt to their setting. They change according to their surrounding. This allows them to influence the immune system into releasing healthy bioactive chemicals that improve signaling between the brain and ovaries. Better signal coordination reverses premature ovarian aging by preventing cell death. It also improves follicular activation for a balanced and regular menstrual cycle. Stem cell therapy holds disease progression and prevents the development of cardiovascular disorders and osteoporosis.

Stem Cell Hospital in Pakistan

Evidence from clinical and preclinical trials indicates that stem cell therapy can not only prevent ovarian dysfunction complications but also reverse the situation. Its beneficial effects can be observed by the fact that participants who received an injection in only one ovary, produced follicles in that ovary and not the other.


The stem cell procedure for ovarian failure is regulated by the Food and Drug Administration, USA. Organizations like the R3 Stem Cell Pakistan have assembled teams of stem cell professionals to guide patients and provide ethical stem cell treatments. If you or anyone in your vicinity who is facing fertility challenges feel free to consult at (051-8896711) | info@r3stemcell.pk

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